Mixing of these substances can increase the severity and risk of side effects, elevating existing risks of side effects to happen, and making potentially life-threatening situation. Trazodone high may be exhibited if it is mixed with any barbiturates, or sedatives (e.g.Valium) but this is definitely not a thing to consider and do. Alcohol can increase the effects of trazodone and make them additive. Those who are taking Trazodone to get ‘’high’’ know that it will not give them euphoric high like other abused drugs, but sedative effects of the drug and various other types of cognitive impairment may be achieved.Īlso, in order to get ‘’high’’ many drug abusers mix trazodone with alcohol, tranqulizers, or other drugs. While trazodone is not a usual drug of abuse, there have been reports that there are individuals who are using the drug recreationally. But, since trazodone affects CNS, there is the potential for abuse or dependence similar after taking other antidepressants. The FDA has no reported data that trazodone can cause euphoria, which is the experience that most drug-abusers want to achieve. It has been also shown that trazodone does not affect the reuptake of norepinephrine or dopamine in the brain. Trazodone dimly blocks presynaptic alpha2-adrenergic receptors and strongly inhibits postsynaptic alpha1 receptors. The overall sedative effect of trazodone is probably the result of the blockage of alpha-adrenergic receptors and modest histamine antagonism at H1 receptor. When used for a long-term period, it may also affect postsynaptic neuronal receptor binding sites. At high doses it acts as a serotonin agonist while in low doses it acts as serotonin antagonist. It is known that trazodone binds to serotonin’s 5-HT2 receptor selectively inhibiting serotonin uptake. The exact mechanism of trazodone’s antidepressant action in man is still not fully understood. Schizophrenia as an adjunct to improve negative symptoms.It is off-labeled used for following disorders: In 1981, FDA first approved trazodone under the brand name Desyrel.įDA approved (label use) indications for trazodone are: Common Brand names for trazodone are: Oleptro, Desyrel, Desyrel Dividose. This drug is available in the form of immediate-release and extended release oral tablets in doses of 50 mg, 75 mg, 100 mg, 150 mg and 300 mg. This medicine does not exacerbate psychotic symptoms in patients with schizophrenia or psychosis disorders, thus it can be also used for this treating depressive symptoms in such patients. Studies showed that it is very useful in treating depressive disorders linked with insomnia and anxiety. Trazodone has been shown to be effective for the treatment of major depressive disorders and other types of depressive disorders. It belongs to the class of drugs known as serotonin modulators that works by affecting serotonin level in the brain. Trazodone is a Generic name for an antidepressant drug that is used to treat symptoms of depression. How long trazodone stay in your system?.How to know if I someone is trazodone abuser or addict?.What studies tell about Trazodone ‘’high’’ potential?.
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